Search results for "phage phi-2"

showing 2 items of 2 documents

Genomic evolution of bacterial populations under coselection by antibiotics and phage

2017

Bacteria live in dynamic systems where selection pressures can alter rapidly, forcing adaptation to the prevailing conditions. In particular, bacteriophages and antibiotics of anthropogenic origin are major bacterial stressors in many environments. We previously observed that populations of the bacterium Pseudomonas fluorescens SBW25 exposed to the lytic bacteriophage SBW25Φ2 and a noninhibitive concentration of the antibiotic streptomycin (coselection) achieved higher levels of phage resistance compared to populations exposed to the phage alone. In addition, the phage became extinct under coselection while remaining present in the phage alone environment. Further, phenotypic tests indicate…

0301 basic medicineMutation rateantibiotic resistancemedicine.drug_class030106 microbiologyAntibioticsBiologyPseudomonas fluorescensmedicine.disease_causeMicrobiologyEvolution MolecularBacteriophage03 medical and health sciencesAntibiotic resistanceMutation RateDrug Resistance BacterialGeneticsmedicineBacteriophagesexperimental evolutionSelection GeneticEscherichia coliEcology Evolution Behavior and Systematics2. Zero hungerExperimental evolutionta1182biology.organism_classificationsublethal antibiotic concentrationsAnti-Bacterial AgentsPhenotypeLytic cyclephage resistanceStreptomycinta1181phage phi-2Genome BacterialBacteria
researchProduct

Genomic evolution of bacterial populations under co-selection by antibiotics and phage

2017

Bacteria live in dynamic systems where selection pressures can alter rapidly, forcing adaptation to the prevailing conditions. In particular, bacteriophages and antibiotics of anthropogenic origin are major bacterial stressors in many environments. We previously observed that populations of the bacterium Pseudomonas fluorescens SBW25 exposed to the lytic bacteriophage SBW25Φ2 and a noninhibitive concentration of the antibiotic streptomycin (coselection) achieved higher levels of phage resistance compared to populations exposed to the phage alone. In addition, the phage became extinct under coselection while remaining present in the phage alone environment. Further, phenotypic tests indicate…

phage resistancephage phi-2experimental evolutionPseudomonas fluorescenssublethal antibiotic concentrationsantibioottiresistenssi
researchProduct